NEW STEP BY STEP MAP FOR PKRRATING

The interfacial residues are extremely conserved amongst eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements reveal that the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations guidance a design where by activating RNA serves as a scaffold to bind numerous PKR monomers, growing

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